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Doctors often recommend that people keep their LDL levels under 100 milligrams per deciliter, and that people at very high risk reduce their LDL under 70. All the patients were taking cholesterol-lowering statins, most at high doses.
Experts said the findings were the most important since the first statins trials were published two decades ago.
Repatha decreased LDL-C from a median of 92 to 30 mg/dL when added to statin therapy, showing a reduction of 59% at week 48 that was continued across the trial.
No one disputes that heart disease is a major medical problem. "However, for lower risk patients this study still leaves payers with significant ammunition to restrict access".
Aiming to address questions about its cognitive effects, researchers at Brigham and Women's Hospital in collaboration with Brown University and the University of Geneva ran cognitive tests on almost 2,000 people enrolled in a two-year study of the drug.
If all 325,000 eligible people in the United Kingdom were to be treated, 2,200 potentially fatal heart emergencies would be avoided every year. The drug's mechanism of action was discovered by studying people with mutations to the gene for PCSK9 that allowed them to maintain exceptionally low cholesterol levels.
Repatha and Praluent, which belong to a class called PCSK9 inhibitors, are especially expensive because they would be taken for such a long time. Those on the highest tier might include specialty medicines that could cost the patient hundreds of dollars even with coverage.
The new study provides much stronger evidence that it saves lives. After diving deeper into the data, we think it will be sufficient to change treatment guidelines, and our assumptions for net USA prices-going from roughly $10,000 today to $8,000 annually over the next couple of years as payers loosen restrictions-still hold.
The Repatha study results are being presented and discussed today at the American College of Cardiology annual meeting.
Patients who were given Repatha experienced a 27 per cent reduction in the risk of heart attack, 21 per cent reduction in stroke and 22 per cent reduction in coronary revascularization.
Half of the patients were asked to take optimal quantity of statins along with Repatha. Doctors say some patients have had trouble getting a new cholesterol-lowering drug, Repatha, that costs $14,000 a year, because of the restrictions.
There were no additional side effects beyond those seen with statins alone.
Previous research had raised the possibility that evolocumab, sold under the brand name Repatha by Amgen, may have a damaging effect on memory and cognitive function.
After she ran into the store, she called the cops and AlSabah locked up the shop after the victim said her captor was armed. She says the man took her money, wallet and phone and drove her to several ATMs and took her money.
They have asked for improvements in compensation, youth team development, equipment, staffing, travel expenses and other areas. In an embarrassing and widely mocked moment, one high school team even beat the US women.
Denver Cat Company owner Sana Hamelin was at Colorado's state Capitol for the Mile High City's Women's Day rally. Democratic congresswomen are staging a walkout Wednesday in support of "A Day Without a Woman".
With the Big Bang Theory nearing its conclusion, CBS has greenlighted a new series that is inspired by the hit comedy TV show. Young Sheldon will focus on the childhood of character Sheldon Cooper, who is played in the original show by Jim Parsons .
Referring to the expressways constructed during his tenure, Akhilesh said: "May be people want bullet trains over expressways". The SP veteran said this was not the first time that party has faced defeat in elections.
Coach Tyronn Lue was not at practice Wednesday at Cleveland Clinic Courts and will not travel with the team later in the day. It was his most jams in a game since 2009. "They destroyed us", Van Gundy told reporters.
In 1993, the same fault system hosted a 6.4-magnitude natural disaster in Long Beach, California, killing a total of 115 people. The disparate data have different resolution scales and depth of penetration providing a "nested survey" of the region.
At least one of the Syrian missiles was intercepted by Israel's cutting-edge "Arrow" antimissile system, Israeli media reported. It was a rare admittance by the Israeli Air Force (IAF) that it carried out strikes on Syria, according to the Times of Israel.
It features every successful (and not so successful) Nintendo release running from the first in 1977 right up to the 2017 Switch. But the fact that GameStop issued a press release about a restock - normally a mundane event - certainly says something.
Northwestern needed its big three: Scottie Lindsey , Vic Law , and Bryant McIntosh to show up today in order to beat Vanderbilt. So everything that he did against Northwestern - good and bad - was foreshadowed to some degree over the previous 34 games.
Tottenham manager backs Vincent Janssen to succeed
Spurs have only once had a better overall record at this stage of a top-flight campaign - in their title-winning 1960-61 season. They generally do such a good job of limiting their opponents that Forster isn't worked often - that may be for the best.
U.S. stocks step back while overseas markets rally
CURRENCIES: The euro from dipped to $1.0746 from $1.0749 late Thursday, and the British pound fell to $1.2367 from $1.2358. A Wall Street sign in front of the New York Stock Exchange in the Manhattan borough of New York January 27, 2015.
State Unemployment Rate Stays Put
Therefore, nonfarm payroll employment is really a count of the number of jobs, rather than the number of persons employed. The nation's preliminary unemployment rate was 4.8 percent in January, up from a revised 4.7 percent in December.
Internet can't handle Clear Knee Mom Jeans
Called "the mullet of the jeans world" by reviewer PartyMomJeans, Topshop's latest design is certainly attracting attention. Confused shoppers, take note of Topshop's directions: "Wear them folded at the cuffs to keep them looking cool ".
AJ Styles Throws Shane McMahon Through A Car Window
The Miz and Maryse have physically attacked and called out John Cena and Nikki Bella in recent weeks, and it has become too much. Similarly, he could fight The Undertaker, a match many thought would happen at WrestleMania this year.
Turkey summons Dutch envoy over Rotterdam police action
Protesters wave flags outside the Dutch consulate in central Istanbul's Istiklal Avenue, the main shopping road of Istanbul. Rutte said he was anxious about the damage to the Netherlands' image in the world if the far right wins the election.
Elon Musk offers to fix Australian power network in 100 days
Would you bet against Elon Musk? "Already reached out looking forward to our discussion", Mr Weatherill said on Twitter . Apparently, Elon Musk is 100 percent behind Rive on this, which is what Cannon-Brookes challenged in the tweet above.
Federal Judge Not Ready to Rule on Revised Travel Ban
He said although the revised order issued on Monday was narrower in scope, it still could be challenged on constitutional grounds. Should the legal argument prove consistently successful, it could be the basis for a permanent turnover of the executive order.
Women's Day marchers target Trump on abortion and
Roughly three-quarters of US teachers are women, according to the National Center for Education Statistics . The day also evolved into the Day Without A Woman protest in some cities across the globe.
Google buys Kaggle in boost to data play
Wednesday's news comes after a host of announcements Tuesday aimed at boosting Google's cloud partner ecosystem. Dr Fei Fei Li, the company's chief scientist for cloud and machine learning, announced the new technology.